Summary Information
The formatting will be different, but clicking on the “Fluoxetine and suicide” title from the last page should produce something that looks like this:
Fluoxetine and suicide: A meta-analysis of controlled trials of treatment for depression.
- Author(s):
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Beasley, Charles M., Eli Lilly & Co, Lilly Research Laboratories Div of Clinical Neurosciences, Indianapolis, IN, US
Dornseif, Bruce E.
Bosomworth, Janet C.
Sayler, Mary E.
et al.
- Source:
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International Clinical Psychopharmacology, Vol 6(Suppl 6), Jun 1992. pp. 35-57.
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Publisher:
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US: Lippincott Williams & Wilkins.
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Abstract:
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Conducted a meta-analysis of data from 17 double-blind clinical controlled trials in patients with major depressive disorder comparing fluoxetine (n = 1,765) with a tricyclic antidepressant (n = 731) or placebo (n = 569), or both. Multiple data sources were searched to identify patients with suicidal acts. Suicidal ideation was assessed with Item 3 of the Hamilton Rating Scale for Depression, which systematically rates suicidality. Improvement was defined as a decrease from baseline at the last visit during the treatment. The pooled incidence of improvement of suicidal ideation was 72.2% for fluoxetine, 54.8% for placebo, and 69.8% for tricyclic antidepressants. Data do not show that fluoxetine is associated with an increased risk of suicidal acts or emergence of substantial suicidal thoughts among depressed patients. (PsycINFO Database Record (c) 2002 APA, all rights reserved)
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