Neuropsychology

Class 10

1. Application of Chemistry to Membrane

   1. Channels in the Membrane

   2. What channels are there

2. Charging the membrane: The Resting Potential

   1. Charge gradients vs. diffusion gradient.

      1. E.g. potassium

      2. The Nernst Equation for potassium EK = 58log([K]o/[K]i) = -93 mV

      3. Nernst Values for other ions

         1. ENa = + 56 mV

         2. ECl = - 66 mV

      4. Getting to -70 mV

         1. The Goldman equation Em =
                     58log((PK*[K]o+PNa*[Na]o+PCl*[Cl]i)/
                             (PK*[K]i+PNa*[Na]i+PCl*[Cl]o))

         2. Permeability = the ability of an ion to reach equilibrium

         3. Gets us to -67

         4. The Sodium Potassium Pump

            1. 3 NA/2K

            2. gets us to -70

            3. Uses energy